What is ZyMot ICSI (Fertile Chip)?
The Fertile Chip — also known as ZyMot ICSI — is a microfluidic sperm selection system that mimics the conditions of the female reproductive tract, obtaining the best sperm with improved morphology, motility, and low double-strand DNA fragmentation rates. These selected sperm are then used to fertilise the eggs through IVF with intracytoplasmic sperm injection (ICSI).
The chip consists of two chambers connected by a microfluidic channel used for the selection and sperm preparation of spermatozoa free from double-strand DNA fragmentation. It also eliminates the need for semen sample centrifugation and reduces the likelihood of single-strand DNA fragmentation in the recovered sperm.
Thanks to this increasingly popular technique, the risk of recurrent miscarriage poor-quality embryos, and implantation failure is significantly reduced.
When is ZyMot ICSI (Fertile Chip) recommended?
The use of Fertile Chip / ZyMot ICSI is especially recommended when a previous COMET FERTILITY test has shown double-strand fragmentation above 60 %. However, it is a technique we use more and more in our laboratory given the excellent results it delivers.
If you would like more information, do not hesitate to contact us and book a free first consultation with our specialists here.
Important update on Fertile Chip® / Zymot ICSI®
The Fertile Chip® device (later known as Zymot ICSI®), which has been used for years for sperm selection in cases of double-strand DNA fragmentation, is no longer being manufactured and is currently unavailable.
At Love Fertility Clinic, we continue to offer this selection approach through an advanced microfluidic technique developed in-house by our embryology team. This method reproduces and enhances the original system, allowing the selection of high-quality sperm with even improved outcomes.
You can find more information about this technique on our sperm selection using microfluidic technology page.
